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Similarity of Multivariate Methods to Establish Microarray Quality Control Standards

Summary: This article describes a multivariate method based on logistic regression that distinguishes between usable and low-quality digital image spots associated with DNA microarray data analysis. To create a response variable describing spot quality, the authors analyzed the similarity among decisions that were made with control charts applied to quality parameters established in the gene expression measurement literature.

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  • Topics: Quality Control
  • Keywords: DNA microarrays, Gene expression data, Hotelling's T2 statistic, Logistic model, Multivariate, Principal components, Quality control (QC), Regression
  • Author: Wu, Jing; Chimka, Justin R.
  • Journal: Quality Engineering